Explain the “lock-and-key” model for drug action and explain why both codeine and morphine function as analges
Explain the “lock and key” model for drug action and explain why both codeine and morphine function as analgesics.
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June 30th, 2010 at 4:33 am
Codeine is converted to morphine in the body.
Lock and key refers to the fit of the opiate into the opiate receptor and then its stimulation because of the shapes of the two of them. The morphine molecule has a portion that is shaped similarly to the endogenous stimulators of that receptor, the endorphins and enkephalins. Any molecule with the proper three dimentional structure, contour and proper charge distribution can occupy the receptor, the way a key can operate a lock because of the shape of the key and of the lock’s internal conformation.