Explain the “lock-and-key” model for drug action and explain why both codeine and morphine function as analges

Explain the “lock and key” model for drug action and explain why both codeine and morphine function as analgesics.

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This entry was posted on Tuesday, June 29th, 2010 at 6:46 pm and is filed under Analgesic. You can follow any responses to this entry through the RSS 2.0 feed. You can skip to the end and leave a response. Pinging is currently not allowed.

One Response to “Explain the “lock-and-key” model for drug action and explain why both codeine and morphine function as analges”

  1. Yaybob Says:

    Codeine is converted to morphine in the body.

    Lock and key refers to the fit of the opiate into the opiate receptor and then its stimulation because of the shapes of the two of them. The morphine molecule has a portion that is shaped similarly to the endogenous stimulators of that receptor, the endorphins and enkephalins. Any molecule with the proper three dimentional structure, contour and proper charge distribution can occupy the receptor, the way a key can operate a lock because of the shape of the key and of the lock’s internal conformation.

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